Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh C-L, Abiona O, et al. 1) [10, 11]. All study participants were selected from the four traditional Emirates in Kebbi State. The RAAS inhibitors are commonly used in clinical practice as they are beneficial in the management of a range of cardiovascular diseases, such as hypertension, heart failure, myocardial infarction, with not only symptomatic but also prognostic benefit [1]. Transcriptome sequencing and bioinformatics analysis of invasive ductal carcinoma and paracancerous tissues from the same patient were performed to identify the key genes and signaling pathways related to breast cancer . Infections are common both in community-acquired as well as hospital-acquired settings and treatment remains challenging to manage due to the emergence of multi-drug resistant strains such as MRSA (Methicillin-Resistant Staphylococcus aureus). The Basic Local Alignment Search Tool (BLAST) finds regions of local similarity between sequences. Accessibility Mission |. Exploring factors influencing immunization utilization in Nigeriaa mixed methods study. BAY 79-4980 is an investigational drug consisting of rFVIII-FS (s iPSC-Derived Platelets Depleted of HLA Class I Are Inert to - PubMed Although the study was terminated early due to recruitment challenges, it showed that telmisartan reduced 30-day mortality and morbidity among hospitalised patients [54]. JAMA Cardiol [Internet]. HHS Vulnerability Disclosure, Help Comparisons of the risk of myopericarditis between COVID-19 patients and individuals receiving COVID-19 vaccines: a population-based study. Staphylococcus aureus is a major bacterial human pathogen that causes a wide variety of clinical manifestations. Out of the 28 respondents interviewed, only 7 reported an AEFI crisis. PubMed comprises more than 35 million citations for biomedical literature from MEDLINE, life science journals, and online books. Subsequently, hypotheses emerged that the use of medications that interfere with the RAAS axis have an implication on the morbidity, mortality and disease severity by increasing the circulating levels of ACE2 [6, 7]. Some of the respondents were able to classify AEFI into two- mild and serious, while a few of them classified it as severe, moderate and mild. Citations may include links to full text content from PubMed Central and publisher web sites. Background: In university undergraduate nursing programmes, didactic strategies that enable students to learn nursing skills, solve problems and develop reflective and critical thinking and practice are needed. Available from: 10.1080/10641963.2020.1764018. The protease renin converts angiotensinogen to Ang-I, which is subsequently converted to Ang-II by angiotensin-converting enzyme (ACE). Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. official website and that any information you provide is encrypted -. GenBank - PubMed ACE2 can covert Ang-I and Ang-II to angiotensin- [17]. However, one respondent mentioned genetic make-up as a possible cause of AEFI, which was not mentioned in the guideline. One of the strategies we adopt is sensitization of the community on AEFI-RT8, . Available from: Fulton TR, Narayanan D, Bonhoeffer J, Ortiz JR, Lambach P, Omer SB. A database of human genes and genetic disorders. As shown in Table Table1,1, a total of 28 participants were recruited for the interview, which included Routine Immunization Officer (RIO) and DSNO from the LGA level and Routine Immunization providers at the primary healthcare level. Block rejection, lower immunization uptake, loss ofconfidence in RI, attack on RI providers, discrimination of RI providers and divorce threats among spouses were the consequences of AEFI. The use and role of RAAS inhibitors therefore during the COVID-19 pandemic have been intensively investigated. Although current studies so far have demonstrated that their commencement solely for protection against COVID-19 infection or its complications is not advantageous, there is strong evidence confirming that they are safe and should be continued by all individuals that have a clear indication to take them for an underlying cardiovascular disease. PubMed uses multiple tools to help you find relevant results: Best Match sort order uses a state-of-the-art machine learning algorithm to place the most relevant citations at the top of your results. However, OMIM now has a new home at omim.org, and users are directed to this site for full record displays. The reninangiotensinaldosterone system (RAAS) has a crucial role in the regulation of sympathetic system and tone and the control of the blood pressure, vascular tone and electrolyte balance. doi: 10.1017/S0007114507839006. and transmitted securely. Kim S, Choi SI, Jang M, Jeong Y, Kang CH, Kim GH. Help Accessibility Careers. 2020 Oct 21 [cited 2022 Apr 7];33(10):9448. official website and that any information you provide is encrypted Comparative impacts of ACE (Angiotensin-Converting Enzyme) inhibitors versus angiotensin II receptor blockers on the risk of COVID-19 mortality. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Effects of milk fermented by Lactobacillus gasseri SBT2055 on adipocyte size in rats. Seluk et al. Seluk M, nar T, Keskin M, iek V, Kl , Kenan B, et al. An autocomplete feature displays suggestions as you type your search terms. Ogawa A, Kadooka Y, Kato K, Shirouchi B, Sato M. Lipids Health Dis. Although it was initially assumed that RAAS inhibitors may relate to worse clinical outcomes and severe disease, data from large studies and meta-analyses demonstrated that they do not have an adverse impact on clinical outcomes or prognosis. The site is secure. I remembered during the yellow fever vaccination campaign, there was a girl down with fever before she fully recovered, the mother insisted that we have to administer a vaccine to the child, after receiving the vaccine, she immediately became unconscious, that was what led to AEFI, she was rushed to the hospital where after series of test and examination, she was said to have malaria-RT6. Ashiru Mohammed Mustapha, Shafiu Muhammad Dansanda, Kehinde Kazeem Kanmodi and Hafsat Abubakar contributed equally to this work. Pattern of adverse events following immunization in nourished and malnourished infants in Kano. Normality tests for statistical analysis: a guide for non - PubMed I witnessed a caregiver refusing to allow her child to take the vaccine. Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. This study aimed to investigate the understanding and experience of Adverse Event Following Immunization (AEFI) among healthcare workers and Routine Immunization (RI) officers. The .gov means its official. You can query these IDs in GenBank. Continued in-hospital angiotensin-converting enzyme inhibitor and angiotensin II receptor blocker use in hypertensive COVID-19 patients is associated with positive clinical outcome. Yan F, Huang F, Xu J, Yang P, Qin Y, Lv J, et al. FOIA PubChem. Pharmacol Res Perspect [Internet]. Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, et al. Available from: Ogunyemi R, Odusanya O. Use of a new global indicator for vaccine safety surveillance and trends in adverse events following immunization reporting 20002015. Consequently, upon infection with SARS-CoV-2, more angiotensin II could accumulate resulting in serious cardiovascular complications [16]. Also,educating caregivers, community sensitization, and dialogue would minimize the consequences of AEFI. Background: Exploration of the genes with abnormal expression during the development of breast cancer is essential to provide a deeper understanding of the mechanisms involved. Available from: 10.1016/j.eclinm.2021.100957. NCBI Help Manual. Conclusions: The knowledge level of healthcare providers on AEFI definition and classification varied and was suboptimal. Available from: Patients taking ACE-i and ARBs who contract COVID-19 should continue treatment, unless otherwise advised by their physician | American Heart Association [Internet]. All the study participants in our study had experienced either non-serious or serious or both types of AEFI. However, no vaccine is perfectly safe. The renin-angiotensin-aldosterone system (RAAS) has a crucial role in the regulation of sympathetic system and tone and the control of the blood pressure, vascular tone and electrolyte balance. Renin-Angiotensin-Aldosterone Inhibitors and COVID-19 Infection On the contrary, some experimental and retrospective observational cohort studies showed a potential protective mechanism, although this effect remains to be seen in large clinical trials. Wu C, Chen X, Cai Y, Xia J, Zhou X, Xu S, et al. A study in Zimbabwe found a gap in knowledge where none of the health workers could precisely define an AEFI[10]. JAMA [Internet]. Vaccines used in the national immunization program are relatively safe and effective. The authors declare that they have no competing interests. Milk fermented by Lactobacillus gasseri SBT2055 influences adipocyte size via inhibition of dietary fat absorption in Zucker rats. In line with the guideline, the respondents in our study explainedthat health education of the caregivers, community sensitization, and community dialogues were strategies adopted to overcome AEFI consequences. With the emergence of SARS coronavirus in 2003, ACE2 was identified as the key receptor that facilitates the entry of the virus into the cells [27]. PubMed ACE and ACE2 enzymes share similar structures with ACE2 being homologous to one of the active sites of ACE [21]. Different possible causes or factors of AEFI were entertained by the respondents. doi: 10.12938/bifidus1996.22.75. Advanced Search Results - PubMed Rate and predictors of early/missed colorectal cancers after - PubMed In the presence of CVD, however, the RAAS could be impaired. 2020;106(19):150311. Bethesda, MD 20894, Web Policies EClinicalMedicine [Internet]. Studies of the identity and physiological function of mesenchymal stromal cells (MSCs) have been hampered by a lack of markers that permit both prospective identification and fate mapping in vivo. Cohen JB, Hanff TC, William P, Sweitzer N, Rosado-Santander NR, Medina C, et al. Lancet Respir Med [Internet]. eCollection 2020 Nov. MethodsX. Ang- [17] acts through the Mas receptor and promotes vasodilation, sodium and water excretion as well as attenuation of inflammation and fibrosis, counter-acting in this way the effects of angiotensin II signalling [6]. [, Santos RAS, Sampaio WO, Alzamora AC, Motta-Santos D, Alenina N, Bader M, et al. Chen Y, Guo Y, Pan Y, Zhao ZJ. Recently, The Lancet published a study on the effectiveness of COVID-19 vaccines and the waning of immunity with time. Radiomics Features of Multiparametric MRI as Novel Prognostic - PubMed Available from: NPHCDA, NCDC, AFENET, CDC, UNICEF, WHO . Angiotensin-converting enzyme 2 protects from severe acute lung failure. An official website of the United States government. The inhibitory activity of turmeric oil was tested in Trichophyton-induced dermatophytosis in guinea pigs. 2022;5(3):222735. I have experienced a case of AEFI which was caused due to anxiety and because the child became afraid by seeing the syringe- RT24. The study was conducted from June to September 2019. Association between renin-angiotensin-aldosterone system inhibitors and clinical outcomes in patients with COVID-19: a systematic review and meta-analysis. The Long Road Toward COVID-19 Herd Immunity: Vaccine Platform - PubMed Home - PMC - NCBI - National Center for Biotechnology Information A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. In fact, the reason that many patients on RAAS inhibitors exhibited signs of severe infection or higher rates of mortality was because of the important pre-existing comorbidities and not the medications used to treat those, i.e. However, this study from Ghana assessed the general knowledge of AEFI by asking the meaning of the acronym AEFI, which differs in the measurement of AEFI definition inour own study. Background: In an experimental study by Monteil et al., it was shown that in engineered human organoids recombinant human-soluble ACE2 markedly reduced the SARS-CoV-2 load by a factor of 10005000 and directly neutralised the virus [59]. Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al. . 2020 Sep 1 [cited 2022 Apr 8];5(9):10206. sharing sensitive information, make sure youre on a federal Whereas, most frequently mentioned clinical features by respondents in our study were persistent crying, fever, fainting attack and swelling and tenderness at injection sites. Federal government websites often end in .gov or .mil. The National Center for Biotechnology Information advances science and health by providing access to biomedical and genomic information. A total of 11 studies included a mixed subgroup (sample population with multiple mixed comorbidities), and 12 studies included a hypertension subgroup (defined as a sample population with hypertension). 2022 July 7; 22: 874, http://apps.who.int/iris/bitstream/10665/206144/1/9789241507769_eng.pdf, https://dhsprogram.com/publications/publication-fr359-dhs-final-reports.cfm, https://www.omicsonline.org/open-access/adverse-events-following-immunisation-aefi-surveillance-in-kwekwe-district-midlands-province-zimbabwe-2157-7560.1000232.php?aid=26597, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622826/, https://www.nigerianstat.gov.ng/nada/index.php/catalog/59. 2009;101:71624. The difference between our study and the Lagos study might be due to study participant selection. government site. Discontinued drugs, 2007: pulmonary-allergy, dermatological, gastrointestinal and arthritis drugs. Month and day are optional. Each respondent was provided with his/her interview transcription for validation before data analysis. Globally, in 2015, 60% of countries in WHO Region of Americas reported at least 10 AEFI per 100,000 surviving infants, 55% in European Region, 43% in Eastern Mediterranean Region, 33% in Western Pacific Region, 27% in South-East Asian Region and 21% in African Region [7]. Careers, Unable to load your collection due to an error. The second phase of the pilot, launching later this month, will include preprints supported by an NIH award . Another respondent also explained that he has seen AEFI due to anxiety. The Kaduna study used scores to assess AEFI knowledge, then categorized it as good and poor knowledge [13]. However, adherence to an up to every-other-day infusion regimen is a barrier to widespread adoption of prophylaxis. He T, Lykov N, Luo X, Wang H, Du Z, Chen Z, Chen S, Zhu L, Zhao Y, Tzeng C. Int J Mol Sci. Controversies of reninangiotensin system inhibition during the COVID-19 pandemic. Available from: Akwataghibe NN, Ogunsola EA, Broerse JEW, Popoola OA, Agbo AI, Dieleman MA. A non-pre-specified interim analysis of 102 participants of the RASTAVI (Renin-Angiotensin System Blockade Benefits in Clinical Evolution and Ventricular Remodeling After Transcatheter Aortic Valve Implantation) trial showed that, even in this high-risk cohort of patients, RAAS inhibitors did not affect the impact or the severity of COVID-19 infection [44]. MeSH Food Sci Biotechnol. Besides, anxiety and coincidental events were mentioned for the AEFI claim. the legs of their children were weak-RT11. Instead of collecting numerical data points or intervene or introduce treatments just like in quantitative research, qualitative research helps generate hypotheses as well as further inves The respondents stated that educating caregivers one-to-one during and after vaccination about the possible clinical event that could follow the use of specific vaccines was expressed by the respondents to prevent misinformation about the vaccines. The SARS-CoV-2 Cytopathic Effect Is Blocked by Lysosome - PubMed HHS Vulnerability Disclosure, Help Omoleke SA, Tadesse MG. A pilot study of routine immunization data quality in Bunza Local Government area: causes and possible remedies. Concerns were therefore expressed, and the hypothesis was generated that patients with underlying chronic cardiovascular comorbidities regularly taking RAS inhibitors would be at higher risk of developing severe infection, as upregulation of ACE2 receptors may translate in high numbers of available entry points that the virus can use to invade the host cells, replicate itself and trigger a potentially severe inflammatory reaction [6, 7]. The BRACE CORONA study included 659 patients with mild-to-moderate COVID-19 infection who were regularly taking ACEIs or ARBs. Hodor controls systemic growth from a subset of enterocytes-interstitial cells-by promoting food intake and insulin/IGF signalling. Unauthorized use of these marks is strictly prohibited. See this image and copyright information in PMC. A veteran respondent shared his experience on AEFI he has ever witnessed as follows. Beyond that, community sensitization and dialogue and reassurance of caregivers were strategies mentioned to overcome community vaccine hesitancy following AEFI. Human and Animal Rights and Informed Consent, Severe acute respiratory syndrome coronavirus2(SARS-CoV-2), Coronavirus disease 2019 (COVID-19), Reninangiotensinaldosterone system (RAAS), Angiotensin-converting enzyme 2(ACE2), {"type":"clinical-trial","attrs":{"text":"NCT04335136","term_id":"NCT04335136"}}. However, no vaccine is perfectly safe, therefore, adverse reactions may occur [1]. Parkinson's disease is a neurological disorder with evolving layers of complexity. Consistent with the NMDAR hypofunction theory of schizophrenia, distinct schizophrenia-related symptoms emerged after adolescence . About the NCBI |. Science (80- ). -, Takahashi H, Fujita T, Suzuki Y, Benno Y. Before Bethesda, MD 20894, Web Policies Available from: 10.1016/j.cbi.2021.109738.
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