The drug is used with standard treatments for cancer, such as chemotherapy, radiation therapy, and hormone therapy. If you have any questions about how long Zometa side effects may last, talk with your doctor. * (Fertility is the ability to become pregnant.) This article looks at the new drugs for bone metastases, how they work, and other possible treatments. You are also welcome to bring your own snacks and beverages of choice. The Food and Drug Administration (FDA) approves prescription drugs such as Zometa to treat certain conditions. Tymlos (abaloparatide) injection, for subcutaneous use. No, Zometa isnt chemotherapy. Medically reviewed by Sanjai Sinha, MD. Theres a relationship between osteoporosis and your parathyroid glands. Most of the fractures occur on the hip, spine, or wrists. Use effective birth control to prevent pregnancy while using this medicine. This should help relieve your symptoms. Ankylosing Spondylitis Pain: Fact or Fiction, https://www.ncbi.nlm.nih.gov/books/NBK539795/, https://www.bones.nih.gov/health-info/bone/bone-health/nutrition/calcium-and-vitamin-d-important-every-age, https://www.ncbi.nlm.nih.gov/books/NBK470248/, https://www.ncbi.nlm.nih.gov/books/NBK585053/, https://www.ncbi.nlm.nih.gov/books/NBK556121/, https://www.ncbi.nlm.nih.gov/books/NBK493191/, https://www.ncbi.nlm.nih.gov/books/NBK535388/, https://theros.org.uk/information-and-support/osteoporosis/treatment/ibandronate/, https://www.ncbi.nlm.nih.gov/books/NBK554489/, https://www.ncbi.nlm.nih.gov/books/NBK499940/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5575294/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5477638/, https://www.ncbi.nlm.nih.gov/books/NBK537269/, https://www.bonehealthandosteoporosis.org/patients/treatment/medicationadherence/, https://www.ncbi.nlm.nih.gov/books/NBK499863/, https://www.ncbi.nlm.nih.gov/books/NBK554550/, https://www.bonehealthandosteoporosis.org/patients/treatment/medicationadherence/side-effects-of-bisphosphonates-alendronate-ibandronate-risedronate-and-zoledronic-acid/, https://www.bonehealthandosteoporosis.org/pagets/pagets-treatment-options/, https://www.ncbi.nlm.nih.gov/books/NBK559248/, https://theros.org.uk/information-and-support/osteoporosis/treatment/zoledronic-acid/, https://www.rheumatology.org/Learning-Center/Medication-Guides/Medication-Guide-Zoledronic-Acid-Reclast, A 20-minute daily walk may improve heart health in those with high CVD risk, Alzheimers: New blood biomarker could predict risk of cognitive decline, Researchers investigate what causes psoriasis and how it spreads, Low-dose atropine eyedrops may delay onset of nearsightedness in children, Heart attack may speed up cognitive decline, study finds. The active drug is also available as a generic medication. You can receive Prolia through IV injections every six months. Prevention of bone resorption stops the release of calcium from the bones into the bloodstream. You may need a second infusion if your calcium level isnt back to normal within 7 days. This is to keep your calcium level from dropping too low. Zometa: Side effects, dosage, cost, uses, and more - Medical News Today Different interactions can cause different effects. They are slowly inflated so that the spine goes back to as near its normal height as possible. Byun J-H, et al. Oral bisphosphonates can cause gastrointestinal side effects, such as heartburn and upset stomach. In clinical studies, the percentage of people with bone issues was 13.1% lower in people treated with pamidronate than those treated with a placebo. This medication is used to treat high blood calcium levels (hypercalcemia) that may occur with cancer. Privacy Policy | Designed by Forge. Its not known how often this side effect may have occurred in clinical studies of the drug. Other treatment options for osteoporosis include denosumab, HRT, salmon calcitonin, and synthetic PTH. Zometa is also used to treat hypercalcemia. If youre breastfeeding or plan to breastfeed, you shouldnt receive Zometa. Medication management is a lot to think about. Parathyroid hormone and parathyroid hormone-related protein analogs in osteoporosis therapy. (2021). And if you have cancer growing in your bones, this can cause your bones to have further damage, weakness, and pain. Symptoms of overdose may include: change in the amount of urine, muscle spasms, muscle weakness, mental/mood changes, irregular heartbeat, seizures. If youre pregnant or planning to become pregnant, you shouldnt receive Zometa. For multiple myeloma or cancer that has spread to your bones, Zometa is usually given once every 3 to 4 weeks. For high calcium levels caused by cancer, Zometa is typically given as a single dose. approved by the Food and Drug Administration (FDA), nonsteroidal anti-inflammatory drugs (NSAIDs), proper nutrition with adequate vitamin D and calcium, accessdata.fda.gov/drugsatfda_docs/label/2016/021858s022lbl.pdf, ncbi.nlm.nih.gov/pmc/articles/PMC5357611/, ncbi.nlm.nih.gov/pmc/articles/PMC7115830/, ncbi.nlm.nih.gov/pmc/articles/PMC8451932/, ncbi.nlm.nih.gov/pmc/articles/PMC7938865/, ncbi.nlm.nih.gov/pmc/articles/PMC6362767/, accessdata.fda.gov/drugsatfda_docs/label/2021/021318Orig1s056lbl.pdf, ncbi.nlm.nih.gov/pmc/articles/PMC8014411/, accessdata.fda.gov/drugsatfda_docs/label/2016/021817s022lbl.pdf, ncbi.nlm.nih.gov/pmc/articles/PMC5768298/, accessdata.fda.gov/drugsatfda_docs/label/2017/208743lbl.pdf, The Relationship Between Osteoporosis and Your Parathyroid Glands, Understanding How Steroids Cause Osteoporosis. Zoledronic acid is also used with cancer chemotherapy to treat bone problems that may occur with multiple myeloma and other types of cancer (such as breast, lung) that have spread to the bones. They are also a treatment for high levels of calcium in your blood. These included fractures (broken bones) and spinal cord compression. Having a doctor who you can feel confident and comfortable with is crucial. And aminoglycosides can sometimes cause problems with how well your kidneys work. Read the Patient Information Leaflet if available from your pharmacist before you start receiving zoledronic acid and each time you get a treatment. Your form submission has been received. It is unknown if this drug passes into breast milk. (2018). If youre breastfeeding or plan to breastfeed, talk with your doctor about treatment options other than Zometa. These are typically given on days 8 and 15 of the first month of treatment. Bone-modifying agents: Complicated to use, A comprehensive review of denosumab for bone metastasis in patients with solid tumors, Impact of bone-targeted treatments on skeletal morbidity and survival in breast cancer, Bone-targeted agents in the treatment of lung cancer, Association of osteonecrosis of the jaw with zoledronic acid treatment for bone metastases in patients with cancer, Osteonecrosis of the jaw: Weighing your risk, Periodontal disease as a risk factor for bisphosphonate-related osteonecrosis of the jaw, Role of bone-modifying agents in metastatic breast cancer: An American Society of Clinical Oncology-Cancer Care Ontario focused guideline update, Interventions for Managing Medication-Related Osteonecrosis of the Jaw, Impact of Bone-Targeted Treatments on Skeletal Morbidity and Survival in Breast Cancer, Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: A CancerCare Ontario and American Society of Clinical Oncology Clinical Practice Guideline, SEOM Clinical Guideline for Bone Metastases From Solid Tumours (2016), Strengthening bones affected by metastases, which reduces pain and fracture risk, Improving progression-free survival and overall survival, Reducing the risk of bone metastases from breast cancer and possibly prostate cancer by a third, Reducing the risk of osteoporosis, which is increased by many treatments for breast and prostate cancer, A mild flu-like syndrome for the first few days after the infusion (most common), Muscle, joint, and/or bone pain (which can arise at any time after treatment), Unusual fractures of the femur (thigh bone) with prolonged use, Atrial fibrillation (an irregular and often rapid heart rhythm), Multiple myeloma or other solid tumors that weren't from breast or prostate cancer, Had recent dental procedures such as tooth extraction. Call your doctor right away if you have serious side effects. There are two infusion bisphosphonates that have been approved by the FDA to treat osteoporosis: They are both excellent alternatives for patients who have failed to receive relief from oral medications, as well as patients for whom an underlying medical condition makes it difficult to swallow a pill. Depending on the drug, you might have this treatment: Doctors can treat bones affected by cancer by using special cement to strengthen them. Heavy drinking can also cause bone loss. Risk of incident atrial fibrillation with zoledronic acid versus denosumab: A propensity scorematched cohort study. The following lists contain some of the key side effects that may occur during Zometa treatment. Ask your doctor about your own risk. Call (833) 394-0600 Parathyroid hormone grows bone and is mainly used for those with very low bone density and who have already had fractures. Your doctor may do various tests to see if the treatment is working. Osteoporosis is. These lists contain up to 10 of the most common mild side effects that can occur with either Zometa or Prolia, as well as mild side effects that both drugs may share. However, treatment options, such as infusion therapy, are available. When the fractures occur in the spine, you may experience a hunched posture, loss of height, and chronic back pain. There is strong evidence that bisphosphonates reduce the incidence of fractures in people with osteoporosis. Zometa is meant to be used as a long-term treatment for multiple myeloma and bone metastases from solid tumors. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. 1-3 Cowan Street For the treatment of multiple myeloma and bone problems caused by the spread of cancer, this medication is usually given every 3 to 4 weeks or as directed by your doctor. There is help and support available. For example, some types of cancer release certain proteins that flow through your bloodstream. Zometa can cause serious kidney problems, especially if you are dehydrated, if you take diuretic medicine, or if you already have kidney disease. By slowing bone breakdown, Zometa can also make it harder for cancer to grow in your bones. Talk with your doctor about the need to prevent pregnancy after you stop using Zometa. This section doesnt contain all drugs that may interact with Zometa. If youre not sure if youll need to get prior authorization for Zometa, contact your insurance company. Solid tumors are cancerous lumps, such as breast and prostate cancers. Increasing Bone Density. Brush and floss your teeth regularly. If you have asthma thats made worse by aspirin, be sure to tell your doctor before starting Zometa treatment. If the cancer is in your spine, Zometa can help lower the risk of the cancer pressing on your spinal cord. If you have bone, joint, or muscle pain while receiving Zometa, talk with your doctor. They give you and your healthcare team more options and better odds of defeating these diseases. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and pre-existing dental problems. The medication is dripped slowly into your vein through a tube. Calcium and vitamin D: Important at every age. Carefully using them can help eliminate specific side effects. Your kidneys work to remove Zometa from your system. Brush and floss your teeth regularly, and use mouthwash if advised by your doctor or dentist. Zometa can treat hypercalcemia (a high level of calcium in your blood) thats caused by the cancer. This medication can also increase the risk of a stroke, heart attack and even death. Your cancer treatment may include chemotherapy, radiation therapy, hormone therapy, or targeted therapy. You should not breastfeed while using Zometa. You may need to have a negative pregnancy test before starting treatment with Zometa. Canada residents can call a provincial poison control center. deRoij van Zuijdewijn C, et al. Strengthening painful bones | Coping with cancer - Cancer Research UK Zometa is sometimes prescribed to people with breast cancer that hasnt spread to other parts of the body. Doctors can treat weakened bones affected by cancer by using either medicines or surgery. A very serious allergic reaction to this drug is rare. . As you grow older, your bones break down. That's because they also have anti-cancer properties. These factors can cause osteoporosis. Thumbigere-Math V, Michalowicz BS, Hodges JS, et al. How Bone Metastases From Cancer Are Treated - Verywell Health These treatments include: You should take Zometa according to your doctors or healthcare providers instructions. But in some cases, you can receive the injections from a healthcare provider at home or be trained how to give yourself injections. However, other drugs in the same class as Zometa are used for osteoporosis. As with all medications, the cost of Zometa can vary. Youll also likely take a daily calcium and vitamin D supplement with Zometa. Zometa also alters the microenvironment in the bone, discouraging tumor growth. Also, cancer in the bones can make them weak and more likely to break. This helps protect and strengthen your bones. In the US - Call your doctor for medical advice about side effects. Such can be the case with a condition like osteoporosis. You may need to have an X-ray to check for fractures. Osteolytic Bone Metastases of Solid Tumors, Osteolytic Bone Lesions of Multiple Myeloma. WebMD does not provide medical advice, diagnosis or treatment. The American Society of Clinical Oncology recommends that people in this group receive Zometa once every 6 months. If your kidneys dont work well, the drug can build up in your body. Reclast (zoledronic acid) injection. Bisphosphonate nephropathy: A case series and review of the literature. Despite the side effects, the majority of medications are well tolerated. Heres some detail on certain side effects this drug may cause. The Reclast brand of zoledronic acid is used in men and women to treat or prevent osteoporosis caused by menopause or by taking steroids. Zoledronic acid may harm an unborn baby. It doesnt come in a biosimilar form. These drugs are available in a variety of formulations. Osteoporosis is a systemic condition characterised by low bone mineral density (BMD) and disrupted bone architecture, which increases in prevalence with age. 2023 Healthline Media UK Ltd, Brighton, UK. (2017). Youll need to have frequent blood tests to check how theyre working. At Infusion Associates, we provide medically-prescribed infusion therapy for patients with chronic conditions in a welcoming and friendly environment.
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